Table 2.

Studies examining dendritic spine and neurite pathology in mouse models of Tauopathy using in vivo two-photon microscopy that are discussed in this review.

Model strain	Method of neuronal labeling	Age at imaging	Brain region imaged	Interval between imaging sessions	Dendritic spine/bouton changes (compared to control)	Presence of neurite dystrophy	References
rTg4510	Crossed with Thy1-YFP transgenic mice	9–10 months	Somatosensory cortex	–	Reduced spine density	–	Kopeikina et al., 2013a
P301S Tau	Crossed with Thy1-YFP transgenic mice	4 months	Somatosensory cortex	3–4 days	Reduced spine density. Decreased spine gain and slightly decreased loss	–	Hoffmann et al., 2013
rTg4510	Viral delivery of calcium indicator YC3.6	8–9 months	Somatosensory cortex	–	Reduced spine density did not correlate with calcium levels in parent dendrite	–	Kopeikina et al., 2013b
rTg4510	Viral delivery of GFP	4, 5, and 6.5 months	Somatosensory cortex	One week	Reduced spine density. Both gain and loss are increased. Bouton turnover decreased.	–	Jackson et al., 2017
rTg4510	Viral delivery of GFP	4,5,6 and 7 months	Somatosensory cortex	One week	Reduced spine and bouton density. Spine turnover increased and bouton turnover decreased.	–	Jackson et al., 2017