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Correlation of the pSMAD1 inhibition with binding of BMP9 pro-domain using SPR measurements. Full and empty dot/quads indicate SPR binders and non-binders respectively, derived either from the second (dot) or the third (quad) immunization blood samples (Bleed 2 and 3). Bmp9.312, 335 and 353 are 3 non-inhibitory hits selected as reference
