Table 3.
Prior to immunization with BMP9, serum from the three selected transgenic rabbits was analyzed for the presence of rabbit and human IgG immunoglobulin chains at different ages
| Rabbit ID | Tg Line Spec | Serum conc., µg/ml |
|||||
|---|---|---|---|---|---|---|---|
| huIgG | huIgM | rbIgG | rbIgM | hukappa | age, weeks | ||
| 500350 | 23223 (FHLC1.1+/+), 1007658 (FHHC1.1-bcl2±), 1016657 (CD79ab+/+), 22826 (IgM-KOΔA1±),22830 (IgM-KOΔA7±) | 11 | bdl | 10 | bdl | 33 | 8 |
| 73 | 70 | 810 | bdl | 380 | 16 | ||
| bdl | 84 | 840 | bdl | 220 | 28 | ||
| 500370 | 23223 (FHLC1.1+/+), 1007658 (FHHC1.1-bcl2+/+), 1016657 (CD79ab+/+), 22830 (IgM-KOΔA7-/-) | 810 | 23 | 1400 | bdl | 3300 | 8 |
| 270 | 150 | 1400 | bdl | 2200 | 12 | ||
| 17 | 180 | 3800 | bdl | 330 | 15 | ||
| 6 | 170 | 680 | bdl | 3700 | 24 | ||
| 500376 | 23223 (FHLC1.1+/+), 1007340 (FHHC1.1-bcl±), 1016657 (CD79ab+/+), 22826 (IgM-KOΔA1±), 25039 (IgM-KOIA1±) | 2900 | 51 | 560 | bdl | 3100 | 8 |
| 1800 | 1400 | 1200 | bdl | 5700 | 12 | ||
| 47 | 210 | 4300 | bdl | 870 | 15 | ||
| 62 | 1100 | 3200 | bdl | 11800 | 24 | ||