Figure 1.

Mouse models of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection provide a broad range of disease phenotypes and pathologies for the study of coronavirus disease (COVID-19). The use of mouse-adapted, adenovirus-induced, and genetically overexpressed strategies, including Ad5-hACE2 (adenovirus type 5–expressing human angiotensin-converting enzyme 2) overexpression described by Han and colleagues, for promoting SARS-CoV-2 binding to ACE2 within the respiratory tract, facilitates viral replication and provides a range of viral tropisms and disease severities with which to study pathogenesis. The figure was created using Biorender. AAV9 = adenovirus-associated virus 9; HFH4 = HNF-3/forkhead homolog 4; K18 = human keratin 18.