Table 1.
Baseline Demographic and Clinical Characteristics of Study Participants
| Total | Half-Dose Combination | Third-Dose Combination | Quarter-Dose Combination | Amlodipine 10 mg | Amlodipine 5mg | Losartan 100 mg | Placebo | |
|---|---|---|---|---|---|---|---|---|
| N | 238 | 36 | 33 | 35 | 33 | 34 | 34 | 33 |
| Age (years) | 64 (11) | 64 (8) | 64 (11) | 60 (12) | 65 (10) | 63 (10) | 66 (12) | 62 (14) |
| Sex | ||||||||
| Male | 166 (70%) | 27(75%) | 25 (76%) | 23 (66%) | 22 (67%) | 22 (65%) | 24 (71%) | 23 (70%) |
| Female | 72 (30%) | 9(25%) | 8 (24%) | 12 (34%) | 11 (33%) | 12 (35%) | 10 (29%) | 10 (30%) |
| BMI (kg/m2) | 25.4 (3.2) | 26.8 (3.7) | 25.3 (3.2) | 24.9 (3.3) | 24.5 (3.1) | 25.3 (3.0) | 25.3 (3.0) | 25.5 (3.2) |
| Current smoker | 41 (17%) | 8 (22%) | 9 (27%) | 3 (9%) | 5 (15%) | 6 (18%) | 4 (12%) | 6 (18%) |
| Drinking | 125 (53%) | 22 (61%) | 17 (52%) | 19 (54%) | 19 (58%) | 16 (47%) | 16 (47%) | 16 (48%) |
| Diabetes | 60 (25%) | 12 (33%) | 7 (21%) | 9 (26%) | 7 (21%) | 8 (24%) | 10 (29%) | 7 (21%) |
| Sitting systolic blood pressure (mmHg) | 154.4 (9.3) | 155.3 (8.7) | 153.7 (10.1) | 154.4 (10.3) | 154.3 (7.4) | 154.6 (10.3) | 154.6 (9.7) | 153.6 (8.9) |
| Sitting diastolic blood pressure (mmHg) | 91.6 (8.9) | 92.4 (8.8) | 91.3 (8.7) | 94.1 (8.7) | 90.68 (11.5) | 92.5 (8.3) | 89.3 (7.5) | 90.5 (8.5) |
Notes: Half-dose combination, amlodipine/losartan/chlorthalidone 2.5/25/6.25mg; Third-dose combination, amlodipine/losartan/chlorthalidone 1.67/16.67/4.17mg; Quarter-dose combination, amlodipine/losartan/chlorthalidone 1.25/12.5/3.13mg; Data are mean (SD) or number of patients (%).