Table 3.
Unadjusted and Adjusted Linear Regression Models for the Association Between Hip BMD (g/cm2), Spine BMD (g/cm2), Chair Rise Time (Seconds), 400-Meter Walk (Seconds), Average Grip (kg), and TFV-DP in DBS (for Every 500-fmol/Punch)
| Models | TFV-DP-DBS (95% CI) | P Value |
|---|---|---|
| Hip Bone Mineral Density (g/cm2) | ||
| Unadjusted Model | −0.021 (−0.040 to −0.0019) | .03 |
| Age Adjusted | −0.020 (−0.040 to −0.0009) | .04 |
| BMI Adjusted | −0.014 (−0.031 to 0.0044) | .14 |
| Total Fat Mass Adjusted | −0.015 (−0.033 to 0.0032) | .10 |
| LBM Adjusted | −0.016 (−0.034 to 0.0010) | .06 |
| Appendicular Lean Mass Adjusted | −0.017 (−0.035 to 0.0005) | .06 |
| Age and BMI Adjusted | −0.008 (−0.025 to 0.0095) | .37 |
| Age and Total Fat Mass Adjusted | −0.011 (−0.0285 to 0.0072) | .23 |
| Spine Bone Mineral Density (g/cm2) | ||
| Unadjusted Model | −0.018 (−0.039 to 0.003) | .09 |
| Age Adjusted | −0.018 (−0.039 to 0.004) | .10 |
| BMI Adjusted | −0.017 (−0.039 to 0.005) | .13 |
| Total Fat Mass Adjusted | −0.018 (−0.040 to 0.004) | .11 |
| LBM Adjusted | −0.014 (−0.034 to 0.006) | .17 |
| Appendicular Lean Mass Adjusted | −0.014 (−0.035 to 0.006) | .16 |
| Age and BMI Adjusted | −0.016 (−0.039 to 0.007) | .17 |
| Age and Total Fat Mass Adjusted | −0.018 (−0.040 to 0.005) | .13 |
| Chair Rise Time (Secondsa) | ||
| Unadjusted Model | 1.2 (−0.1 to 2.3) | .06 |
| Age Adjusted | 0.9 (−0.3 to 2.0) | .14 |
| BMI Adjusted | 1.5 (0.3–2.6) | .02 |
| Total Fat Mass Adjusted | 1.5 (0.3–2.6) | .02 |
| LBM Adjusted | 1.1 (−0.1 to 2.3) | .07 |
| Appendicular Lean Mass Adjusted | 1.1 (−0.1 to 2.3) | .07 |
| Age and BMI Adjusted | 1.1 (−0.1 to 2.4) | .06 |
| Age and Total Fat Mass Adjusted | 1.2 (−0.03 to 2.4) | .06 |
| 400-Meter Walk (Secondsa) | ||
| Unadjusted Model | 14.8 (3.8–25.8) | .01 |
| Age Adjusted | 13.5 (3.2–23.7) | .01 |
| BMI Adjusted | 19.5 (9.9–29.1) | <.001 |
| Total Fat Mass Adjusted | 20.2 (11.0–29.5) | <.001 |
| LBM Adjusted | 15.2 (4.0–26.5) | .01 |
| Appendicular Lean Mass Adjusted | 14.6 (3.4–25.9) | .01 |
| Age and BMI Adjusted | 18.3 (8.4–28.1) | <.001 |
| Age and Total Fat Mass Adjusted | 19.1 (9.6–28.7) | <.001 |
| Average Grip (kg) | ||
| Unadjusted Model | −0.23 (−1.63 to 1.16) | .74 |
| Age Adjusted | −0.14 (−1.55 to 1.26) | .84 |
| BMI Adjusted | −0.19 (−1.65 to 1.28) | .80 |
| Total Fat Mass Adjusted | −0.21 (−1.66 to 1.24) | .77 |
| LBM Adjusted | 0.20 (−0.95 to 1.36) | .73 |
| Appendicular Lean Mass Adjusted | 0.17 (−0.97 to 1.30) | .77 |
| Age and BMI Adjusted | 0.07 (−1.43 to 1.57) | .93 |
| Age and Total Fat Mass Adjusted | −0.01 (−1.49 to 1.48) | .99 |
Significant P values are indicated by italics.
Abbreviations: BMD, bone mineral density; BMI, body mass index; CI, confidence interval; DBS, dried blood spots; LBM, lean body mass; TFV-DP, tenofovir diphosphate.
aLower number = faster time to complete.