Table 1.

Key Aspects of COVID-19 Research from Which Sepsis Researchers Can Learn

Aspect	Message
Heterogeneity	COVID-19 is more homogenous than sepsis, and that has probably been helpful with identifying effective treatments. Sepsis researchers should therefore consider smaller/more homogenous subgroups for study.
Outcome measures	Widespread use of core outcome sets facilitates comparison and pooling across studies. Examples of core outcomes are as follows (7): • Organ dysfunction • Biochemical parameters • Radiological findings • Duration of intervention • Quality of life • Resource use
	Examining homogenous subgroups facilitates additional outcome measures (e.g., severity of lung injury) that would not be relevant to an all-cause sepsis population.
Global collaboration	Global data platforms with a standardized case report form can facilitate pooling of sepsis research.
	National or global coordination of large research projects can streamline sepsis research.
	Popular messaging platforms can be excellent tools to aid trial coordination.

Definition of abbreviation: COVID-19 = coronavirus disease.