Table 1:
protocol | Synergizing with | Technique | Temperature range (⁰C) | Duration session (min) | Number of sessions & frequency | Tumor sites: Proven/routine experimental | refs | |
---|---|---|---|---|---|---|---|---|
Hyperthermia as sensitizer | Chemotherapy | Local | IHT | 39–45 | 60 | 1–12 sessions before, during or after chemo | ||
SFUS | 39–45 | 30–60 | LI | [190] | ||||
MNP | 39–45 | 60 | ||||||
Intraluminal | 39–45 | 60 | BL, RE | [221–224, 400, 401] | ||||
Capacitive | 39–45 | 60 | HN | [402] | ||||
Radiative | 39–45 | 60 | ||||||
Locoregional | Capacitive | 39–45 | 60 | BL, CE, LI, LU, OE, PA | [31, 295–297, 301, 305–308, 403–405] | |||
Radiative | 39–45 | 60 | BL, CE, EX, LI, OE, PA, PE, PO | [311–315, 392, 406–412] | ||||
HIPEC | 40–43 | 30–90 | 1 session during chemo | PE | [327–329, 332] | |||
ILP | 38–39 | 60–90 | 1 session during chemo | EX | [335, 336] | |||
WBH | 39–42 | 60–120 | LU, PA, PO, RE | [35] | ||||
Radiotherapy | Local | IHT | 39–45 | 60 | 1–5 sessions, 1x/2x weekly during RT, before/after RT fraction | BR, HN, PR | [90, 117, 119, 413] | |
SFUS | 39–45 | 60 | PR | |||||
MNP | 39–45 | 60 | BR, PR | [214, 414] | ||||
Intraluminal | 39–45 | 60 | OE, RE | [400, 415, 416] | ||||
Capacitive | 39–45 | 60 | CW, HN, | [269, 417, 418] | ||||
Radiative | 39–45 | 60 | CW, HN, IB, ME, | [253, 254, 257, 265, 267, 268, 419, 420] | ||||
Locoregional | Capacitive | 39–45 | 60 | BL, BO, CE, LI, LU, OE, PA, PR, RE | [292–294, 296, 298, 299, 301–305, 309, 421–423] | |||
radiative | 39–45 | 60 | BL, CE, OE, LI, PA, PR, RE | [272, 406, 410, 412, 424, 425] | ||||
Thermal ablation | n.a. | Local | IHT | 50–100 | <5 | 1 session | BO, BL, BR, HN, IB, LI, KI, LU, OE, PA, PR, TH | [110, 121, 122, 124, 125, 127–142, 144, 145, 147, 149–151, 426] |
SFUS | 50–100 | <5 | BO, BR, CE, IB, LI, KI, OE, PA, PO, PR, TH | [78, 81, 95, 138, 154, 167–169, 171–182, 184, 185, 187, 188] | ||||
IRE | 50–100 | <10 | KI, LI, LU, PA, PR | [201–206] |
BL: bladder, BO: bone (metastases, osteoid sarcoma), BR: brain, CE: cervix/uterus, CW: chest wall, EX: extremities, HN: head&neck, IB: intact breast, KI: kidney, LI: liver, LU: lung, ME: melanoma, OE: oesophagus, PA: pancreas, PO: pelvis other (soft tissue sarcoma/ pediatric tumors), PE: peritoneum, PR: prostate, RE: rectum, TH: thyroid.