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. Author manuscript; available in PMC: 2021 Jan 4.
Published in final edited form as: Int J Hyperthermia. 2020;37(1):711–741. doi: 10.1080/02656736.2020.1779357

Table 1:

General summary of heating techniques, typical goal temperatures, treatment scheme and duration, as well as experimental (italic) and clinically proven applications.

protocol Synergizing with Technique Temperature range (⁰C) Duration session (min) Number of sessions & frequency Tumor sites: Proven/routine experimental refs
Hyperthermia as sensitizer Chemotherapy Local IHT 39–45 60 1–12 sessions before, during or after chemo
SFUS 39–45 30–60 LI [190]
MNP 39–45 60
Intraluminal 39–45 60 BL, RE [221–224, 400, 401]
Capacitive 39–45 60 HN [402]
Radiative 39–45 60
Locoregional Capacitive 39–45 60 BL, CE, LI, LU, OE, PA [31, 295–297, 301, 305–308, 403–405]
Radiative 39–45 60 BL, CE, EX, LI, OE, PA, PE, PO [311–315, 392, 406–412]
HIPEC 40–43 30–90 1 session during chemo PE [327–329, 332]
ILP 38–39 60–90 1 session during chemo EX [335, 336]
WBH 39–42 60–120 LU, PA, PO, RE [35]
Radiotherapy Local IHT 39–45 60 1–5 sessions, 1x/2x weekly during RT, before/after RT fraction BR, HN, PR [90, 117, 119, 413]
SFUS 39–45 60 PR
MNP 39–45 60 BR, PR [214, 414]
Intraluminal 39–45 60 OE, RE [400, 415, 416]
Capacitive 39–45 60 CW, HN, [269, 417, 418]
Radiative 39–45 60 CW, HN, IB, ME, [253, 254, 257, 265, 267, 268, 419, 420]
Locoregional Capacitive 39–45 60 BL, BO, CE, LI, LU, OE, PA, PR, RE [292–294, 296, 298, 299, 301–305, 309, 421–423]
radiative 39–45 60 BL, CE, OE, LI, PA, PR, RE [272, 406, 410, 412, 424, 425]
Thermal ablation n.a. Local IHT 50–100 <5 1 session BO, BL, BR, HN, IB, LI, KI, LU, OE, PA, PR, TH [110, 121, 122, 124, 125, 127–142, 144, 145, 147, 149–151, 426]
SFUS 50–100 <5 BO, BR, CE, IB, LI, KI, OE, PA, PO, PR, TH [78, 81, 95, 138, 154, 167–169, 171–182, 184, 185, 187, 188]
IRE 50–100 <10 KI, LI, LU, PA, PR [201–206]

BL: bladder, BO: bone (metastases, osteoid sarcoma), BR: brain, CE: cervix/uterus, CW: chest wall, EX: extremities, HN: head&neck, IB: intact breast, KI: kidney, LI: liver, LU: lung, ME: melanoma, OE: oesophagus, PA: pancreas, PO: pelvis other (soft tissue sarcoma/ pediatric tumors), PE: peritoneum, PR: prostate, RE: rectum, TH: thyroid.