Table 2:

Overview of clinical applications of local, locoregional and whole-body heating techniques. Open circles represent explorative (small/few phase I/II) use and solid black circles represent many/large phase I/II trials, retrospective analyses or phase III evidence.

	Local hyperthermia and ablation										Locoregional hyperthermia				WBH
	IHT		SFUS		IRE	MNP		Intraluminal	Superficial		EM Locoregional		HIPEC	ILP		References
	HT	ABL	HT	ABL	ABL	HT	ABL		cap	rad	cap	rad
BL: Bladder		○						●			○	○				[55, 149, 216, 217, 221–224, 272, 300–302, 407, 408, 427]
BO: Bone (metastases, osteoid osteoma)		○		●							●					[121, 171, 309]
BR: Brain	●	○		○			○									[80, 118–120, 145, 147, 148, 154, 214]
CE: Cervix/Uterus				●							○/●	●				[31, 167–170, 272, 307, 308, 310]
CW: Chest wall									○	●						[228, 232, 263–266, 417, 418]
EX: Extremities												●		●		[311, 335, 336]
HN: Head & Neck	○	○							●	●/○						[130–133, 257, 269, 413, 419, 420]
IB: Intact breast		○		○						○						[136, 180, 253, 254]
KI: Kidney		○		○	○											[134, 135, 184, 201, 428]
LI: Liver		●	○	○	○						○	○				[50, 104, 106, 107, 112, 124, 125, 139, 143, 144, 190, 201, 204, 305, 306, 412]
LU: Lung		●			○						○				○	[103, 108, 127–129, 140–142, 206, 292–297]
ME: Melanoma										●						[267, 268]
OE: Oesophagus		●		○				○			○	○				[122, 137, 185, 404, 405, 410, 415, 423, 426]
PA: Pancreas		○		○	○						○	○			○	[138, 179, 201–203, 315, 403, 406, 422]
PE: Peritoneum												○	●			[320, 322–325, 327–329, 392, 411]
PO: Pelvis other: soft tissue sarcoma/ pediatric tumors				○								●			○	[181, 182, 311–314]
PR: Prostate	○	○/●		●	○	○					○	○				[78, 81, 90, 95, 117, 150, 151, 172–178, 205, 298, 299, 414, 424, 425]
RE: Rectum								○			○	●			○	[35, 272, 303, 304, 400, 401, 416]
TH: Thyroid		●		○												[130–133, 187]