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. 2021 Jan 4;12:1. doi: 10.1186/s13287-020-02006-w

Table 1.

Point of care devices for bed side separation of SVF

Medical devise Manufacturer Closed/semi-closed Separation method Proceeded fat quantity (g) Process duration (min) Cell yield/g of fat
Device/control (D/C)		 Cell viability
D/C or D		 References

Celution R 800/CRS

StemSource 900/MB

 Cytori Therapeutics, Inc Closed Enzymatic 300 g 90 2.41 × 106/NP NP [57, 58]
GID SVF-1, SVF-2 GID Group, Inc Closed Enzymatic 300 g 90 0.425 × 106 ± 0.047 × 106/0.795 × 106 ± 0.228 × 106 50–84% [56, 57, 64–67]
Icellator® Tissue Genesis, Inc. Closed Enzymatic 60 80 0.25–2.0 × 106 64.5 ± 11.4 [57, 68, 69]
Puregraft™ Eurosilicone Semi-closed Mechanical 250 100 0.25 × 106 ± 0,07 × 106/0.79 × 106 ± 0.228 × 106 77% [57]
Stem.pra® Proteal Closed Mechanical 200 110 0.535 × 106 ± 0.209 × 106/0.795 × 106 ± 0.228 × 106 69% [57]
Cha-Station™ PNC International Co., Ltd. Semi-closed

Mechanical

Enzymatic

 200 90 0.05 × 106 NA [57, 70]
Sepax® Biosafe Grop SA Semi-closed Mechanical 300 90–120 2.6 ± 1.2 × 105/ML NA [55, 57]
UNISTATION™ NeoGenesis Closed Not provided NP NP 1.1 × 105 ± 1.1 × 105/2.0 × 105 ± 1.7 × 105 NA [71]
Lipokit MaxStem Medi-Khan’s Semi-closed Enzymatic NP 88–120 0.35 × 106 50–84 [56, 70]

Processing with the different devices is reported regarding the closed or semi-closed systems and their efficiency to separate SVF in terms of fat quantity, cell yield and viability, and duration. These devices provide all-in-one single-use kit for the SVF separation and might also contain their GMP-grade proteolytic enzymes. NP not provided and, NA not applicable