Table 2.
Annual Rates of Cardiovascular Disease (combined Myocardial Infarction or Stroke), and Myocardial Infarction and Stroke separately in Systemic Lupus Erythematosus (SLE), Diabetes Mellitus (DM), and General Population (Non-SLE/Non-DM) Medicaid patients (2007–2010)
| Number of Patients | Mean Age at Event, years (SD) | Number of Events | Person-years, mean (SD) | IR* (95% CI) | IRR**a (Reference: DM) (95%CI) | IRR**b (Reference: General population) (95%CI) | |
|---|---|---|---|---|---|---|---|
| Cardiovascular Disease | |||||||
| General Population | 160,848 | 52.56 (8.78) | 657 | 1.73 (1.14) | 2.36 (2.19–2.55) | 0.34 (0.33–0.34) | 1.0 (ref.) |
| DM | 80,424 | 49.38 (9.92) | 1060 | 1.86 (1.11) | 7.07 (6.66–7.51) | 1.0 (ref.) | 2.98 (2.90–3.06) |
| SLE | 40,212 | 45.04 (12.49) | 672 | 1.86 (1.11) | 8.99 (8.34–9.70) | 1.27 (1.23–1.30) | 3.78 (3.67–3.89) |
| Myocardial Infarction | |||||||
| General Population | 160,848 | 53.40 (8.24) | 233 | 1.73 (1.14) | 0.83 (0.73–0.94) | 0.28 (0.27–0.29) | 1.0 (ref.) |
| DM | 80,424 | 49.87 (9.40) | 454 | 1.87 (1.11) | 3.01 (2.75–3.30) | 1.0 (ref.) | 3.60 (3.49–3.71) |
| SLE | 40,212 | 46.80 (12.16) | 243 | 1.87 (1.11) | 3.23 (2.85–3.66) | 1.07 (1.04–1.10) | 3.85 (3.72–3.99) |
| Stroke | |||||||
| General Population | 160,848 | 52.15 (8.99) | 433 | 1.73 (1.14) | 1.55 (1.41–1.70) | 0.37 (0.36–0.38) | 1.0 (ref.) |
| DM | 80,424 | 49.16 (10.30) | 642 | 1.87 (1.11) | 4.27 (3.95–4.61) | 1.0 (ref.) | 2.74 (2.66–2.82) |
| SLE | 40,212 | 44.14 (12.59) | 448 | 1.87 (1.11) | 5.97 (5.44–6.55) | 1.40 (1.36–1.44) | 3.82 (3.71–3.94) |
SLE= Systemic Lupus Erythematosus, DM=Diabetes Mellitus, SD= Standard Deviation
*
IR = incidence rate, annual CVD event rate per 1,000 person years
**
IRR= incidence rate ratio
a
Diabetes Mellitus used as the reference group;
b
General Population used as the reference group.