Table 2. Echocardiographic and Electrocardiographic Parameters of Amiodarone, Propafenone and Control Groups.
| Amiodarone (n = 68) | Propafenone (n = 40) | Control (n = 50) | P value | |
|---|---|---|---|---|
| Echocardiographic parameters | ||||
| Heart rate (beat per minute) | 72.1 ± 10.8 | 73.0 ± 11.4 | 75.8 ± 13.3 | 0.278 |
| QRS (ms) | 94.8 ± 13.0a | 100.5 ± 13.2b | 90.7 ± 6.7a | < 0.001 |
| QT interval (ms) | 412.1 ± 37.0a | 384.1 ± 30.7b | 377.5 ± 26.8b | < 0.001 |
| QTc interval (ms) | 450.1 ± 27.5a | 421.8 ± 25.3b | 412.1 ± 23.6b | < 0.001 |
| Tp-e interval (ms) | 85.2 ± 18.9a | 69.9 ± 10.3b | 66.5 ± 10.6b | < 0.001 |
| Tp-e/QT ratio | 0.20 (0.18 - 0.22)a | 0.18 (0.16 - 0.20)b | 0.17 (0.15 - 0.20)b | < 0.001 |
| cTp-e interval (ms) | 93.8 ± 20.3a | 78.6 ± 13.7b | 75.1 ± 11.8b | < 0.001 |
| Tp-e/QTc ratio | 0.18 (0.16 - 0.20)a | 0.16 (0.15 - 0.19)b | 0.16 (0.14 - 0.18)b | < 0.001 |
| iCEB | 4.4 ± 0.6a | 3.9 ± 0.5b | 4.2 ± 0.4a | < 0.001 |
| iCEBc | 4.8 ± 0.6a | 4.3 ± 0.6b | 4.6 ± 0.4c | < 0.001 |
| Echocardiography parameters | ||||
| LVEF (median (IQR)) (%) | 50.0 (35.0 - 55.0)a | 55.0 (53.0 - 55.0)b | 56.0 (55.0 - 60.0)b | < 0.001 |
| LA diameter (cm) | 4.6 ± 0.6a | 4.0 ± 0.3b | 3.7 ± 0.3c | < 0.001 |
| IVS thickness (mm) | 11.7 ± 1.1a | 11.0 ± 0.8a | 10.1 ± 1.0b | < 0.001 |
| PW thickness (mm) | 10.6 ± 1.1a | 10.1 ± 1.0a | 9.0 ± 1.0b | < 0.001 |
| Advers events | ||||
| TdP (%) | 1 (1.5) | 0 (0.0) | - | 0.999* |
| Non-sustained VT (%) | 0 (0.0) | 1 (2.5) | - | 0.370* |
*Depending on the expected count, Pearson Chi-square, Fisher exact or Fisher-Freeman-Halton test was used. Descriptive statistics were presented as number (%). Multiple comparisons were marked with superscript letters in the table. As same letters notify no significant difference between the groups, different letters mean a significant difference between the groups. Tp-e: T wave peak-to-end; iCEB: index of cardio-electrophysiological balance; iCEBc: corrected iCEB; LVEF: left ventricular ejection fraction; LA: left atrial; IVS: interventricular septum; PW: posterior wall; VT: ventricular tachycardia; TdP: torsades de pointes; Tp-e: transmural dispersion of repolarisation; cTp-e: corrected Tp-e.