Table 2. ATMPs Borderline Source: Alliance for Regenerative Medicine 2019.

Advance therapy medicinal products borderlines
Advantages	Disadvantages
Highly personalized therapy	Complex manufacturing
Direct application through infusion	High up-front cost
Longer lasting effect	One-time treatment
Address complex diseases	Specific regulatory and pharmacovigilance demands
Improving health-related quality of life	Highly specific storage requirements: short shelf life
Fewer hospitalizations, comorbidities and associate treatment

ATMPs: advanced therapy medicinal products.