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[Preprint]. 2020 Dec 23:2020.12.22.422708. [Version 1] doi: 10.1101/2020.12.22.422708

Fig. 4. Model diagram of potential damage to tight junction integrity and epithelia following infection by SARS-CoV-2.

Fig. 4.

Left - intact epithelial TJ complex and barrier function from lumen to interstitium. Cells are close together with solid colored lines representing TJ proteins ZO1, ZO2, ZO3, and PALS1. Right - compromised epithelial TJ complex (dotted colored lines) following SARS-CoV-2 infection and expression of E protein resulting in barrier disruption and increased paracellular transepithelial leak.