Figure 1.

TNA treatment ameliorated neuronal loss and promoted neurological functional recovery after TBI. (A) Neurons were determined by Nissl staining. Many normal neurons (arrows) were detected in Sham group. TNA-treated mice had much more neurons on day 7 compared with NS-treated or TNA+ICI-treated mice (*P < 0.05, **P < 0.01). (B) NSS score on day 0, 1, 3, 5 and 7 after treatment. In Sham group no neurological deficit was found. Compared with NS-treated mouse, TNA-treated mice had less severe symptoms from day 3 after treatment (*P < 0.05, **P < 0.01). Compared with TNA+ICI-treated mice, TNA-treated mice also showed better recovery from day 5 (^#P < 0.05). TNA+ICI-treated mice did not recover better than NS-treated mouse within 7 days. (scale bar: 50 μm.).

Abbreviations: TNA, tanshinone IIA; TBI, traumatic brain injury; IC, ICI 182,780.