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. 2020 Dec 31;16:3239–3250. doi: 10.2147/NDT.S265478

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© 2020 Chen et al.

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IL-10 knockdown abolished the effect of TNA on microglial M2 polarization in vitro. (A) Western blot for IL-10 and β-actin. It showed that IL-10 siRNA knocked down around 85% of IL-10 expression induced by LPS. (B) qPCR for M1 microglia (iNOS, TNFα and IL-1β) M2 microglia (CD206, arginase 1 and Ym1) demonstrated that the effect of TNA on TNA on microglial M2 polarization was reversed by IL-10 knockdown (**P<0.01, ^{^}P>0.05).

Abbreviations: TNA, tanshinone IIA; LPS, lipopolysaccharide; iNOS, inducible nitric oxide synthase; TNFα, tumor necrosis factor α.