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. 2021 Jan 4;129(1):017004. doi: 10.1289/EHP7600

Figure 5.

Figure 5A is a set of eight graphs titled active concentration at 50 percent- uppercase l (Phenotypes “active”: 70.2 percent), Expo uppercase l (Phenotypes “active”: 36.2 percent), point-of-departure uppercase l (Phenotypes “active”: 93.6 percent), regulatory oral noncancer reference doses uppercase l (Phenotypes “active”: 51.1 percent), active concentration at 50 percent- uppercase h (Phenotypes “active”: 95.7 percent), Expo uppercase h (Phenotypes “active”: 51.1 percent), point-of-departure uppercase h (Phenotypes “active”: 97.9 percent), and regulatory oral noncancer reference doses uppercase h (Phenotypes “active”: 76.6 percent) depicting the Bayesian-Modeling-estimated of the designed mixtures by plotting effective concentration at 10 percent (Total concentration in microMolar), ranging from 10 begin superscript negative 2 end superscript to 10 begin superscript 4 end superscript in increments of 10 begin superscript 2 end superscript (x-axis) for HUVECs, iCell Cardiomyocytes, iCell Endothelial cells, iCell Hepatocytes, and iCell Neurons. Figure 5B is a graph plotting active concentration at 50 percent- uppercase l, active concentration at 50 percent- uppercase h, Expo uppercase l, Expo uppercase h, point-of-departure uppercase l, point-of-departure uppercase h, regulatory oral noncancer reference doses uppercase l, and regulatory oral noncancer reference doses uppercase l (y-axis) across effective concentration at 10 percent (Total concentration in microMolar), ranging from 10 begin superscript negative 2 end superscript to 10 begin superscript 4 end superscript in increments of 10 begin superscript 2 end superscript (x-axis).

(A) The Bayesian modeling-estimated effective concentrations (EC10) (median with 90% credible interval) of the designed mixtures. The dashed vertical line is the total chemical concentration for each designed mixture. The different phenotypes in each cell type (see color legend on top of the figure) are displayed by the same color. Cyan is HUVECs, dark magenta is iCell cardiomyocytes, green is iCell endothelial cells, dark orange is iCell hepatocytes, and dark blue is iCell neurons. The percent of phenotypes active was based on the posterior median EC10 values compared with the undiluted designed concentration. (B) The probability density plot shows the distribution of all estimated EC10 for each mixture. See acronym explanations and description of the designed mixtures in Table 1. All data are included in a Supplemental Excel file.