Skip to main content
. 2021 Jan 4;129(1):017004. doi: 10.1289/EHP7600

Figure 6.

Figure 6A is a set of three box and whisker plots titled iCell Neurons (Total Outgrowth), iCell Cardiomyocytes (beats per minute, 15 minutes), and HUVECs (Mean Tube Length), plotting Effect (Fraction of Vehicle), ranging from 0 to 1 in increments of 0.2, and I A, C A, and Fitting (y-axis) across Total concentration in micromolar, ranging from 10 begin superscript negative 1 end superscript to 10 begin superscript 5 end superscript in increments of 10 begin superscript 2 end superscript (x-axis). Figure 6B is a box and whisker plot plotting Cell Number, cell Number, Cell Number, Nuclei Mean Area, Mitochondrial Intensity, Nuclei Mean Area, Nuclei Mean Area, All Cell Mean Area, Mitochondrial Integrity, Mitochondrial Intensity, Cytoplasmic Integrity, Mean Tube Length, Mitochondrial Integrity, Mitochondrial Intensity, Mean Tube Length, Total Cells Body Area, Cell Number, Mitochondrial Integrity, Total Process, Cytoplasmic Integrity, Mitochondrial Integrity, Cell with Significant Growth, Mean Outgrowth, Total Tube Area, Total Tube Length, uppercase a t p, Cell Number, Cytoplasmic Integrity, Total Outgrowth, Decay to rise ratio-90 minutes, Peak Spacing – 15 minutes, Peak Rise time – 15 minutes, Decay to Rise Ration – 15 minutes, Peak Width – 15 minutes, Total branches, Beats Per Minute – 15 minutes, Peak Width – 90 minutes, Beats Per Minute – 90 minutes, Peak Rise time – 90 minutes, Peak Decay time – 90 minutes, Peak Spacing – 90 minutes, Peak Amplitude – 15 minutes, Peak Amplitude – 90 minutes, Total Tube Length, and Total Tube Area (y-axis) across effective concentration at 10 percent (total concentration in microMolar), ranging from 10 begin superscript negative 2 end superscript to 10 begin superscript 4 end superscript in increments on 10 begin superscript 2 end superscript (x-axis) for HUVECs, iCell Cardiomyocytes, iCell Endothelial cells, iCell Hepatocytes, and iCell Neurons. Figure 6B is a box and whisker plot plotting Concentration Addition (C A), Independent Action (I A), and Designed mixture curve fitting (y-axis) across effective concentration at 10 percent (total concentration in microMolar), ranging from 10 begin superscript negative 2 end superscript to 10 begin superscript 4 end superscript in increments on 10 begin superscript 2 end superscript (x-axis).

Comparison of curve-fitting, IA, and CA estimated median effective concentration (EC10) with 95% confidence limits, and each box and whisker plot shows the median, first/third quartile, and a distance of 1.5 times the IQR. (A) The representative examples to compare the concentration–response-profile for fitting and IA/CA predicted result. Box and whisker plot represents the distribution of the estimated EC10. The points are the in vitro experimental data. (B) The comparison of estimated EC10 across all phenotypes. The shaded bars represent median and 95% confidence limits for the prediction from CA or IA (colors correspond to those in panel C) (C) Box and whisker plots summary of the estimated EC10; the points represent values outside 1.5 times the IQR. All data are included in a Supplemental Excel file. Note: CA, concentration addition; IA, independent addition; IQR, interquartile range.