Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 1;113(1):80–87. doi: 10.1093/jnci/djaa047

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 3. — Working model for uveal melanoma (UM) malignant transformation process throughout time in different genetic backgrounds. Germline MBD4^mut/BAP1^mut: population with MBD4/BAP1 germline mutation. Following the G_αq activating mutation, secondary mutational events in each genetic background are indicated, along with their association with either disomy 3 (D3) or monosomy 3 (M3). SE = SF3B1 or EIF1AX mutation. Relative lifetime risk of UM is represented by the expansion size and color from normal melanocytes to UM. Dashed and full red arrows indicate the rate of accumulation of somatic mutations throughout time (low and high, respectively).