Table 4.
Type 2 Poliovirus Shedding in Stool Samples From Participants After 1 or 2 Doses of Monovalent Type 2 Oral Poliovirus Vaccine (Per-Protocol Population)
| Sheddinga | Groups 1 and 2 After Dose 1 (n = 97) | Group 2 After Dose 2 (n = 47) |
|---|---|---|
| Days 7, 14, 21, and 28 | ||
| Shedders, No./total (%) | 30/31 (97) | 11/20 (55) |
| SIE, median (95% CI), log10 CCID50 | ||
| Overall | 4.03 (3.11–4.80) | 0.69 (.0–2.06) |
| Among shedders | 4.32 (3.24–4.84) | 2.06 (.70–3.01) |
| Day 7 | ||
| Shedders, No./total (%) | 85/92 (92) | 20/44 (45) |
| Median (95% CI), log10 CCID50 | ||
| Overall | 5.88 (5.44–6.36) | 0 (.0 to ≤2.75) |
| Among shedders | 5.91 (5.72–6.63) | 4.42 (2.91–6.09) |
| Day 14 | ||
| Shedders, No./total (%) | 55/62 (89) | 13/29 (45) |
| Median (95% CI), log10 CCID50 | ||
| Overall | 5.11 (4.19–5.72) | 0 (.0–3.0) |
| Among shedders | 5.41 (4.59–6.06) | 4.69 (3.00 to ≥8.25) |
| Day 21 | ||
| Shedders, No./total (%) | 44/66 (67) | 10/35 (29) |
| Median (95% CI), log10 CCID50 | ||
| Overall | 2.89 (≤2.75 to 3.63) | 0 (.0–.0) |
| Among shedders | 4.05 (3.17–5.31) | 3.02 (≤2.75 to 4.05) |
| Day 28 | ||
| Shedders, No./total (%) | 34/68 (50) | 9/37 (24) |
| Median (95% CI), log10 CCID50 | ||
| Overall | 1.38 (.0–3.19) | 0 (.0–.0) |
| Among shedders | 4.83 (3.69 to ≥8.25) | 3.16 (2.78 to ≥8.25) |
Abbreviations: CI, confidence interval; SIE, shedding index end point.
aRate and extent of viral shedding in polymerase chain reaction–positive participants. The allowable window for stool samples to contribute to the SIE computation was ±2 days from the nominal sampling day.