Table 1.

Cytokine Alterations During Cp1038 Infection

Cytokine	Cytokine Level, Median (Maximum–Minimum), pg/g Lung Tissue
	Uninfected	Week 2	Week 4	Week 5	Week 6
TNF-⍺	8505 (9772–3782)	10 797 (17 713–8288)	29 203 (60 623–11 237)	11 320 (82 055–41)	45 802 (118 117–3098)
IL-1⍺	<1.3 LOD (<1.3–1234)	2972 (3596–1774)a	22 577 (29 165–2609)b	26 292 (29 165–14 504)a	20 364 (30 100–2022)
IL-1β	1538 (1773–1206)	1333 (1542–661)	1661 (5483–993)	4520 (7888–2436)	2530 (6988–600)
IL-23	<4.2 LOD (<4.2–<4.2)	<4.2 (1475–<4.2)	6326 (10 164–<4.2)	2535 (5189–1740)	1412 (2521–<4.2)
MCP-1	55 239 (63 056–48 920)	51 419 (65 628–25 626)	39 420 (91 082–19 351)	6826 (12 181–3110)a	14 809 (23 045–7345)
GM-CSF	22 661 (30 537–14 005)	43 975 (63 419–24 935)	19 882 (43 825–9228)	3076 (12 087–849)a	9117 (13 551–5728)
IFN-β	176 147 (217 878–72 299)	61 506 (110 102–35 924)	106 309 (199 120–44 928)	19 288 (32 180–5139)a	52 164 (76 054–23 309)
IL-6	252 102 (310 612–199 122)	381 933 (494 675–191 489)	255 359 (448 848–182 647)	79 278 (140 224–46 324)a	166 889 (199 945–89 619)
IL-10	7464 (8543–6506)	7028 (8747–4215)	5528 (10 967–4476)	2579 (5026–1366)	3602 (4490–1998)
IL-17A	<1.8 LOD (<1.8–<1.8)	597 (2148–287)	6058 (33 146–<1.8)	1584 (9086–1114)	7139 (10 988–2839)
IFN-ɣ	<0.8 LOD (<0.8–<0.8)	<0.8 (<0.8–<0.8)	425 (9028–<0.8)	5389 (11 077–302)	1579 (7823–<0.8)
IL-27	8218 (9903–7062)	7571 (10 257–4366)	10 802 (13 740–6819)	15 178 (16 217–6054)	9175 (19 327–4563)
IL-12p70	<0.7 LOD (<0.7–<0.7)	<0.7 LOD (<0.7–<0.7)	<0.7 LOD (<0.7–<0.7)	<0.7 LOD (<0.7–<0.7)	<0.7 LOD (<0.7–<0.7)

Abbreviations: GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; IL-1α (etc), interleukin 1α (etc); LOD, limit of detection; MCP-1, monocyte chemoattractant protein 1; TNF, tumor necrosis factor.

^aSignificant at P = .04.

^bSignificant at P = .02.