Fig 2. Effect of two ineffective doses of trazodone and gabapentin alone or in combination on mechanical hyperalgesia 3 (A), 7 (B) and 14 (C) days following rat sciatic nerve ligation.

The results are expressed as pain threshold (in grams) recorded 1 h after treatment administration. ###P<0.001 vs naïve group; *P < 0.05, **P<0.01 vs vehicle CCI group; §P<0.05, §§P<0.01 vs trazodone-gabapentin CCI group. n = 6 animals/group.