Fig 6. An M-locus-linked sex distorter gene drive targeting female-specific flight genes.

Male mosquitoes modified to contain a site specific nuclease targeting a haploinsufficient female flight gene (myo-fem) in the M-locus would be released to mate with wild type females. All male progeny from these matings would inherit the nuclease, which would inactivate the intact female flight gene inherited from the mother. All female progeny from these matings would inherit one disrupted allele of the female-specific flight gene and therefore be unable to fly, blood feed, or mate to produce future offspring.