Table 1. Summary of DNA methylation in Verticillium dahliae wild-type (WT) and heterochromatin protein one deletion mutant (Δhp1) as measured by whole genome bisulfite sequencing calculated over 10 kb non-overlapping windows.

Genotype	Avg. weighted mCG*	Avg. weighted mCHG*	Avg. weighted mCHH*	Avg. fraction mCG*	Avg. fraction mCHG*	Avg. fraction mCHH*
WT	0.0040	0.0037	0.0034	0.097	0.097	0.088
Δhp1	0.0030	0.0030	0.0032	0.082	0.083	0.079

Avg. Weighted, The average of total methylated cytosines in a given context divided by total cytosines in that context in a 10 kb windows; Avg. Fraction, The total cytosine positions with a read supporting methylation divided by total cytosines in a specific context in a 10 kb window; mCG, methylated cytosine residing next to a guanine; mCHG, methylated cytosine residing next to any base that is not a guanine next to a guanine; mCHH, methylated cytosine residing next to any two bases that are not a guanines. *, values are significantly different (p-value<0.001), Mann-Whitney U-test. The distribution of values and p-values for individual comparisons are shown in Figure 1—figure supplement 1.