Key resources table.

Reagent type (species) or resource	Designation	Source or reference	Identifiers	Additional information
Biological sample (Human)	Human gingival biopsies	Periodontology department, King’s College London
Antibody	anti-COLVI (Rabbit monoclonal)	Abcam	Cat #ab182744, RRID:AB_2847919	IHC (1:500)
Antibody	anti-ACTA2 (Mouse monoclonal)	Abcam	Cat #ab7817, RRID:AB_262054	IHC (1:200)
antibody	anti-MCAM (Rabbit monoclonal)	Abcam	Cat #ab75769, RRID:AB_2143375	IHC (1:100)
Antibody	anti-KI67 (Rabbit polyclonal)	Abcam	Cat #ab15580, RRID:AB_443209	IHC (1:100)
Antibody	anti-SOX2 (Rabbit monoclonal)	Abcam	Cat# ab92494, RRID:AB_10585428	IHC (1:100)
Antibody	anti-CD79A (Rabbit monoclonal)	Abcam	Cat# ab79414, RRID:AB_2260147	IHC (1:100)
Antibody	anti-AEBP1 (Rabbit polyclonal)	Atlas Antibodies	Cat# HPA064970, RRID:AB_2685394	IHC (1:200)
Commercial assay or kit	ImmPRESS Excel Staining Kit, Anti-Rabbit Ig	Vector Laboratories	Cat# MP-7601, RRID:AB_2336533
Chemical compound, drug	UltraPure BSA (50 mg/mL)	ThermoFisher Scientific	Cat# AM2618	0.04%
Commercial assay or kit	Chromium Single Cell 3’ Library and Gel Bead Kit v3	10X Genomics	Cat# PN-1000092
Commercial assay or kit	Chromium Single Cell B Chip Kit	10X Genomics	Cat# PN-1000074
Commercial assay or kit	Whole Skin Dissociation Kit, human	Miltenyi Biotec	Cat# 130-101-540
Software, algorithm	CellRanger Version 4	10X Genomics	RRID:SCR_017344
Software, algorithm	Seurat Version 3.0	R Bioconductor	RRID:SCR_007322 https://satijalab.org/seurat/
Software, algorithm	Enrichr	Chen et al., 2013	RRID:SCR_001575
Software, algorithm	CytoTRACE	R Bioconductor	https://cytotrace.stanford.edu
Software, algorithm	NicheNet	GitHub	https://github.com/saeyslab/nichenetr
Other	GRCh38	CellRanger, 10X Genomics	https://support.10xgenomics.com/single-cell-gene-expression/software/downloads/latest
Other	DAPI stain	Invitrogen	D1306, RRID:AB_2629482	(1 ug/mL)