Table 1.

Known and novel effects of Fc glycans on the pharmacokinetics of mAbs

Results	Study	Species
No preferences for Fc glycans	Huang et al.17 Jones et al.18	Mouse Human/monkey
High-mannose-type glycans are cleared faster	Kanda et al.19 Chen et al.20 Goetze et al.21 Alessandri et al.22 Higel et al.23 This study	Mouse Human Human Human Rabbit Rat
Man5 is not cleared faster	Chen et al.20 Yu et al.24	Human Mouse
Enzymatic conversion of ManX(6–9) to Man5	Chen et al.20 Goetze et al.21 Alessandri et al.22 Yu et al.24 Higel et al.23	Human Human Human Mouse Rabbit
Hybrid type glycans are cleared faster*	Kanda et al.19 This study	Mouse Rat
Monoantennary glycans behave similarly to complex not hybrid type glycans	This study	Rat
Afucosylation has (almost) no effect	Kanda et al.19 This study	Mouse Rat
Galactosylation potentially decreases clearance	This study	Rat
Sialylation has no effect	This study	Rat

* While Kanda et al reported hybrid-type glycans (Man5G0 and Man5G1) to be cleared slower than high-mannose type, we found an at least similar effect of hybrid-type glycans (Man5G0).