Table 2.

Total antibody-based PK values. Values in bold tend to show a difference with the wildtype (p < .05). However, none of the results are significant after multiple testing correction

	Reference	M5	Mono	ST3
cmax [µg/mL]	28.0 ± 10.1	30.6 ± 2.2	32.3 ± 2.8	38.7 ± 10.3
AUC(0-inf) [day*µg/mL]	231 ± 26.6	180 ± 29.1	251 ± 34.5	288 ± 71.5
CL [mL/day/kg]	4.4 ± 0.5	5.7 ± 1.1	4.1 ± 0.6	3.7 ± 1.0
Vss [mL/kg]	95.2 ± 10.4	94.9 ± 16.0	82.1 ± 6.3	74.0 ± 26.7
t1/2 [days]	15.8 ± 1.6	12.6 ± 1.0	15.1 ± 2.2	14.5 ± 2.1