Table 2.
Activation and inactivation parameters of wildtype Cav1.38b-11-43S and S652L8b-11-43S.
| |
Activation |
Inactivation |
||||||
| α1 subunit | V0.5 (mV) |
Slope (mV) |
Vrev (mV) |
n | V0.5 (mV) |
Slope (mV) |
Non-inactivating (%) |
n |
| Cav1.38b 11 43S | -13.40 ± 0.63 |
7.60 ± 0.15 |
64.75 ± 0.72 |
29 | -39.94 ± 0.97 |
4.94 ± 0.19 |
10.82 ± 0.78 |
21 |
| S652L8b-11-43S | -25.50 ± 0.74*** |
7.61 ± 0.14 |
58.26 ± 0.71*** |
18 | -58.92 ± 0.77*** |
4.93 ± 0.24 |
7.57 ± 1.37* |
13 |
Parameters were obtained from fitting normalized activation curves (G/Gmax) or normalized steady-state inactivation curves (I/Icontrol). All values are presented as mean ± SEM and originate from >3 independent transfections. Statistics: student´s t-test, *p < 0.05, ***p < 0.001. n, number of experiments. V0.5, half-maximal activation/inactivation voltage; Vrev, reversal potential.