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. 2020 Dec 31;15(1):38–52. doi: 10.1080/19336950.2020.1859260

Table 4.

Normalized inactivation kinetic parameters of mutation R498L

 
 Remaining ICa [%]
  
  
α1 subunit r50 r100 r250 r500 r1000 r5000 n  
Cav1.38a-42 69.41 ± 2.54 57.47 ± 2.65 39.14 ± 2.35 26.48 ± 1.94 17.72 ± 1.56 8.05 ± 0.94 28  
Cav1.38a-11-42 72.97 ± 3.29 61.20 ± 3.12 40.67 ± 2.69 25.87 ± 2.13 15.61 ± 1.80 6.47 ± 1.25 13  
R498L8a-11-42 70.66 ± 2.88 60.22 ± 3.00 42.17 ± 2.93 27.64 ± 2.46 16.67 ± 1.72 6.90 ± 0.84 22  

r-values represent the fraction of remaining ICa after 50, 100, 250, 500, 1000 and 5000 ms upon a 5 s depolarization to the voltage of maximal inward current (Vmax). All values are presented as mean ± SEM and originate from >3 independent transfections. Statistics: one-way ANOVA followed by Bonferroni multiple comparison post-test R498L8a-11-42 in comparison to Cav1.38a-42 and Cav1.38a-11-42; n, number of experiments.