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. 2020 Sep 24;9(1):1824643. doi: 10.1080/2162402X.2020.1824643

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — A2AR knock-out released CAR-T cells from exhaustion induced by adenosine. (a) Scheme of repetitive tumor challenge assay. (b) Proliferation of AKO and P4 cells after repetitive tumor challenge in the presence of CADO. (c) Specific lysis by AKO and P4 cells after three rounds of CRL5826 challenge in the presence of CADO. (d) Immune checkpoint gene expression of AKO and P4 cells after three rounds of CRL5826 stimulation in the presence of CADO. *P < .05; **P < .01; ****P < .0001 were determined by two-way ANOVA test. Data were represented as mean ± s.d. of three technical replications per assay. The assays were repeated three times in (b–c) and two times in (d).