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. 2020 Sep 24;9(1):1824643. doi: 10.1080/2162402X.2020.1824643

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — A2AR knock-out P4 CAR-T enhanced tumor killing in PDX models in vivo. (a) Scheme of in vivo assay to test the anti-tumor function of AKO cells. (b) Mesothelin and CD73 expression in two PDX models. (c) Fold changes of tumor volume after CAR-T cells intratumor injection in #1 PDX model. The translucent line represented the tumor volume fold for individual mice, the solid line indicated the mean value. (d) The size and weight of resected tumors derived from mice sacrificed at 70 d after CAR-T cells injection in #1 PDX model. (e) Analysis of T cell types in peripheral blood at 42 d after CAR-T cell injection in #1 PDX model. Comparison was made with CD3+ cells or CD8+ cells in P4 and AKO group. (f) Fold changes of tumor volume after CAR-T cells intratumor injection in #2 PDX model. The translucent line represented the tumor volume fold for individual mice, and the solid line indicated the mean value. **P < .01 was determined by two-way ANOVA test. Data were represented as mean ± s.d.