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. 2020 Dec 30;10(1):1862520. doi: 10.1080/2162402X.2020.1862520

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — The differentially expressed genes (DEGs) of the four molecular subtypes shared the same gene signature and functional annotations. (A), The Venn diagram of DEGs from the molecular subtypes showed 11 overlapping up-regulated genes. (B), The Venn diagram of DEGs from the molecular subtypes showed no overlapping down-regulated gene. (C), KEGG enrichment analysis of biological processes related to the up-regulated genes in the different molecular subtypes. (D), The Venn diagram of biological processes related to the up-regulated genes by KEGG showed 4 overlapping pathways participating in immune regulation. (E), By GSEA with all transcripts ranked by the log2 (Fold Change) in each subtype, 15 overlapping pathways related to immunity were discovered. (F), The results of antigen processing and presentation in the different molecular subtypes, one of 15 overlapping pathways, were displayed. (G), The results of the inflammatory response in the different molecular subtypes, one of 15 overlapping pathways, were displayed