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Schematic representation of bivalent and bispecific Fab-like antibodies. The CH1 constant domain of human IgG1 (dark gray) was fused to anti-NKG2D ISVD (white) whereas the CL constant domain (light gray) was fused to the same anti-NKG2D ISVD to generate bivalent Fab-like antibodies or to an anti-HER2 (C7b) or anti-FMDV ISVDs (gray and black respectively) to build bispecific Fab-like antibodies. (a): HA tag, (b): hexahistidine tag
