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. 2020 Dec 29;10(1):1854529. doi: 10.1080/2162402X.2020.1854529

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Blockade of MICA-mediated NK cell activation by soluble NKG2D bvFab. Human recombinant MICA protein and/or anti-2B4 mAb (ratio 1/1) were immobilized on microplates. IL2-stimulated human NK cells and soluble antibodies (150 nM) were then added. After 2 h of incubation, NK cell activation was assessed by quantification of cell surface CD107a by flow cytometry. The percentage of CD107a-positive NK cells obtained in the presence of MICA and anti-2B4 mAb without any soluble anti-NKG2D mAb was normalized to 100%. Ctl = soluble anti-NKG2D mAb. Irrel = FMDV bvFab. Each bar represents the mean value ± SD of 2 independent experiments