Table 2. Comparison of the pharmacokinetic parameters of tamsulosin 0.2 and 0.4 mg capsules in the fed state.
| Pharmacokinetic parameters | Tamsulosin 0.4 mg under fed state (n = 22) | Tamsulosin 0.2 mg under fed state (n = 22) | Geometric mean ratio (90% confidence interval) |
|---|---|---|---|
| Tmax (h) | 5.00 [3.00–10.00] | 6.00 [4.00–10.00] | |
| Cmax (μg/L) | 13.43 ± 4.11 | 5.51 ± 1.76 | 2.41 (2.18–2.68) |
| AUClast (h·μg/L) | 185.94 ± 56.30 | 90.76 ± 25.01 | 2.04 (1.93–2.18) |
| AUCinf (h·μg/L) | 199.61 ± 66.57 | 100.30 ± 29.67 | 1.98 (1.86–2.11) |
| Cmax/dose (/L) | 0.034 ± 0.010 | 0.028 ± 0.009 | 1.21 (1.09–1.34) |
| AUClast/dose (h/L) | 0.46 ± 0.14 | 0.45 ± 0.13 | 1.02 (0.96–1.09) |
| AUCinf/dose (h/L) | 0.50 ± 0.17 | 0.50 ± 0.15 | 0.99 (0.93–1.06) |
| Vz/F (L) | 34.35 ± 11.11 | 39.10 ± 13.87 | |
| CL/F (L/h) | 2.22 ± 0.76 | 2.22 ± 0.82 | |
| t1/2 (h) | 11.19 ± 3.02 | 12.56 ± 2.32 |
Data are presented as the mean ± standard deviation except for Tmax which is expressed as the median [minimum-maximum].
Cmax, maximum plasma concentration; Tmax, time of maximum plasma concentration; AUClast, area under the curve from the time of administration to last measurable concentration; AUCinf, AUC from administration to infinity based on the last concentration; Cmax/dose, dose-normalized maximum plasma concentration; AUClast/dose, dose-normalized AUClast; AUCinf/dose, dose-normalized AUCinf; Vz/F, apparent volume of distribution during the terminal phase; CL/F, apparent clearance; t1/2, terminal elimination half-life.