Table 3. Effect of food on the pharmacokinetic parameters of the tamsulosin 0.4 mg capsule.
| Pharmacokinetic parameters | Tamsulosin 0.4 mg under fed state (n = 22) | Tamsulosin 0.4 mg under fasted state (n = 22) | Geometric mean ratio (90% confidence interval) |
|---|---|---|---|
| Tmax (h) | 5.00 [3.00–10.00] | 4.50 [2.00–6.00] | |
| Cmax (μg/L) | 13.43 ± 4.11 | 16.15 ± 3.26 | 0.80 (0.72–0.89) |
| AUClast (h·μg/L) | 185.94 ± 56.30 | 201.08 ± 48.12 | 0.91 (0.86–0.97) |
| AUCinf (h·μg/L) | 199.61 ± 66.57 | 211.87 ± 53.51 | 0.93 (0.87–0.99) |
| Vz/F (L) | 34.35 ± 11.11 | 30.99 ± 6.68 | |
| CL/F (L/h) | 2.22 ± 0.76 | 2.01 ± 0.54 | |
| t1/2 (h) | 11.19 ± 3.02 | 10.93 ± 1.95 |
Data are presented as the mean ± standard deviation except for Tmax which is expressed as the median [minimum-maximum].
Cmax, maximum plasma concentration; Tmax, time of maximum plasma concentration; AUClast, area under the curve from the time of administration to last measurable concentration; AUCinf, AUC from administration to infinity based on the last concentration; Cmax/dose, dose-normalized maximum plasma concentration; AUClast/dose, dose-normalized AUClast; AUCinf/dose, dose-normalized AUCinf; Vz/F, apparent volume of distribution during the terminal phase; CL/F, apparent clearance; t1/2, terminal elimination half-life.