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. 2021 Jan 5;26(1):629–645. doi: 10.1007/s11030-020-10176-1

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© The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature 2021

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 5 — Plots showing the inhibitory activity for the potential drug leads. The hydrolytic activity of SARS-CoV-2 M^pro was measured in the presence of different concentrations of drugs. Curves produce best fits for calculating the IC₅₀ values. Reprinted with permission from Ref. [67]