Table 1.

Association between SIK2 expression and clinicopathologic characteristics of 180 GC patients in the study cohort.

Characteristics	Cases	SIK2 expression		P‐value
		High	Low
Gender
Male	131	72	59	0.8673
Female	49	26	23
Age (years)
≤ 60	74	37	37	0.3625
> 60	106	61	45
Tumor size (cm)
≤ 5	108	56	52	0.4460
> 5	72	42	30
Histology differentiation
Poor	102	53	49	0.4549
Well or moderate	78	45	33
Depth of tumor invasion
T1	5	4	1	0.6704
T2	18	9	9
T3	41	23	18
T4	116	62	54
Lymphatic metastasis
N0	44	32	12	<0.0001*
N1	73	46	27
N2	40	12	28
N3	23	8	15
Clinical stage
Ⅰ	24	19	5	0.0025*
Ⅱ	52	33	19
Ⅲ	104	46	58
Lymphatic invasion
Absent	44	32	12	0.0055*
Present	136	66	70
Nerve/Venous invasion
Absent	116	56	60	0.0291*
Present	64	42	22

^*Indicates statistical significance.