Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Scheme of PKCβ driven nuclear localization of Lin28B connected to a TET3‐mediated positive feedback loop. KRAS promotes nuclear localization of Lin28B by PKCβ, which directly phosphorylates Lin28B. Nuclear Lin28B indirectly elevates TET3 expression by repressing the bioactivity of let‐7i, and increased TET3 can feed back to promote Lin28B expression, which maintains the stemness of PC cells.
