Fig. 1.

EV nomenclature. Size and cellular origin of different EV subpopulations with regard to commonly used terminology are schematized. Since EVs are heterogeneous and current isolation techniques depend on EV size, density, or insufficiently characterized surface markers, EV fractions obtained during the different isolation procedures are most likely impure mixtures of various EV fractions, for example, Exos and MVs. Therefore, current recommendations of the ISEV in the MISEV consensus are aiming to consolidate common classification standards for EV research in the future (see pink box as published in [2]). MISEV, Minimum Information for the Study of Extracellular Vesicles.