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The hypermethylation of miRNA promoters leads to miRNA silencing and the disinhibition of target genes. a A genomic view of miR-429, miR-141-3p, and miR-126-3p’s promoter region methylation in GCs of PCOS (red) and control (gray) groups in IGV browser. b Expression changes of miR-429, miR-141-3p, and miR-126-3p and target genes were verified by RT-qPCR (N = 3; P = 3). c Methylation level change of promoter region of miR-429, miR-141-3p, and miR-126-3p (N = 3; P = 3). Color figure online
