Table 3.
Antiproliferative activity in vitro of compounds with strong telomerase inhibitory activity (IC50<1 μM) against A375, MDA-MB-231, MGC-803, SMMC-7721 and SGC-7901 cell linesa.
| IC50 (μM)b |
|||||
|---|---|---|---|---|---|
| Compounds | A375 | MDA-MB-231 | MGC-803 | SMMC-7721 | SGC-7901 |
| A2 | 11.03 ± 1.54 | 25.06 ± 2.10 | 17.26 ± 2.21 | 8.07 ± 1.30 | 56.91 ± 1.24 |
| A5 | 20.09 ± 0.62 | –c | 15.22 ± 0.41 | – | 25.36 ± 0.59 |
| A16 | 10.09 ± 0.52 | – | – | – | – |
| A20 | 8.92 ± 0.69 | 19.50 ± 1.00 | 6.29 ± 0.36 | – | 10.22 ± 0.65 |
| A27 | – | – | – | – | – |
| A33 | 11.21 ± 0.69 | 9.89 ± 0.44 | 8.76 ± 0.25 | 9.67 ± 0.82 | 10.01 ± 0.51 |
| B27 | – | – | – | – | – |
| B33 | – | – | – | – | – |
| BIBR1532 d | 57.58 ± 0.21 | – | – | – | – |
| ADM d | 0.58 ± 0.20 | 0.51 ± 0.12 | 0.42 ± 0.08 | 0.79 ± 0.13 | 0.82 ± 0.43 |
Negative control 0.1% DMSO, no activity.
aThe data represented the mean of three experiments in triplicate and were expressed as means ± SD.
bThe IC50 value was defined as the concentration at which 50% survival of cells was observed. The results are listed in the table.
cNot observed in the tested concentration range (>100 μM).
dUsed as a positive control.