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. 2020 Nov 20;20:218–226. doi: 10.1016/j.omtm.2020.11.010

Figure 2.

Figure 2

The Nancy histological index and colon length of the 2.5% and 3.5% DSS-administered animals

Histological analysis was carried out on formalin-fixed, paraffin-embedded (FFPE) colon samples from experimental groups, and the levels of inflammation and ulceration were scored as described in Materials and Methods. (A) The Nancy histological index (UC) of the distal colon for the various treatment groups with 2.5% DSS. (B) The Nancy histological index (UC) of the distal colon for the various treatment groups with 3.5% DSS. (C) Effect of the modified E. coli MDS42 strains containing psiTNF and invasive plasmids on the colon length in the treatment group with 2.5% DSS. (D) Effect of the modified E. coli MDS42 strains containing psiTNF and invasive plasmids on the colon length in the treatment group with 3.5% DSS. Vehicle: tap water-administered animal group; siTNF, animals treated by modified E. coli MDS42 strains containing psiTNF and invasive plasmids; DSS, colon specimen of the DSS-treated animals; DSS-siTNF, animals administered DSS and treated by modified E. coli MDS42 strains containing psiTNF and invasive plasmids; pSuper, animals treated by modified E. coli MDS42 strains containing pSuper (empty vector) and invasive plasmids; DSS-pSuper, animals administered 2.5% DSS and treated by modified E. coli MDS42 strains containing pSuper (empty vector) and invasive plasmids. Data represent the mean (SD). ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.