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. 2020 Nov 20;20:218–226. doi: 10.1016/j.omtm.2020.11.010

Figure 3.

Figure 3

mRNA expression levels of proinflammatory cytokines in vehicle treated controls and 3,5% DSS induced colitis with and without treatment with the modified E. coli MDS42 strains containing psiTNF

(A) TNF mRNA expression measured on distal colon samples. (B) IL-1a mRNA expression measured on distal colon samples. (C) IL-1b mRNA expression measured on distal colon samples. (D) IL-6 mRNA expression measured on distal colon samples. Vehicle, tap water-administered animal group; DSS, colon specimen of the 3.5% DSS-treated animals; DSS-siTNF, animals administered 3.5% DSS and treated by modified E. coli MDS42 strains containing psiTNF and invasive plasmids. Data represent the means (SD). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.