Figure 7.

Sequencing of the 16S RNA V3 and V4 hypervariable regions

Characterizing microbiome changes by sequencing the bacterial 16S RNA V3 and V4 hypervariable regions in the vehicle treated control, DSS induced colitis, and the DSS induced colitis that were treated with the modified E. coli MDS42 strain that either carried an empty plasmid or the psiTNF. (A) the relative abundance of the various bacterial genera; (B) Differences in the microbioime composition as expressed by the weighted principal component analysis (wPcoA).