Table 1.
Study characteristics and patient demographics.
| Study | Comparator (n) | Age, YearsMean (SD) or Median (Range) | Male n (%) | Surgery type | Surgery number (%) | Intraoperative Coagulation Medications |
|---|---|---|---|---|---|---|
| Nenezic 2019 [20,28] | VISTASEAL 2C (109) | 64(44–84) | 76 (70) | Bypass Grafting | 95 (87.2%) | Heparin 100IU/kg before clamping for bypass and 50IU/kg for AVG |
| Arteriovenous Graft Formation | 14 (12.8%) | |||||
| Manual Compression (57) | 61(22–82) | 31 (54) | Bypass Grafting | 47 (82.5%) | ||
| Arteriovenous Graft Formation | 10 (17.5%) | |||||
| Chetter 2017 [19] | VISTASEAL 1C (110) | 68(8.9) | 95 (86) | Bypass grafting | 53 (48.2%) | According to the respective institution's standards (included systemic heparin regime/dose, reversal with protamine, and timing of reversal) |
| Endarterectomy requiring patch angioplasty | 27 (24.5%) | |||||
| Aneurysm resection and graft replacement | 18 (16.4%) | |||||
| Iliofemoral bypass | 4 (3.63%) | |||||
| Other type of surgery (≤1 each) | 8 (7.3%) | |||||
| Manual Compression (57) | 67(10.3) | 39 (68) | Bypass grafting | 27 (47.4%) | ||
| Endarterectomy requiring patch angioplasty | 11 (19.3%) | |||||
| Aneurysm resection and graft replacement | 13 (22.8%) | |||||
| Iliofemoral bypass | 2 (3.5%) | |||||
| Other type of surgery (≤1 each) | 1 (1.8%) | |||||
| Saha 2012 [31] | TISSEEL 2C (70) | 63(12.6) | 30 (43) | Bypass grafting | 39 (55.7%) | Heparin 100IU/kg before clamping for bypass and 50IU/kg for AV shunts |
| Arteriovenous shunt | 31 (44.3%) | |||||
| Manual Compression (70) | 66(11.5) | 37 (53) | Bypass grafting | 28 (40%) | ||
| Arteriovenous shunt | 42 (60%) | |||||
| Saha 2011 [30] | TISSEEL 1C (26) | 63(12.7) | 21 (81) | Bypass grafting | NR | Mean heparin units (IU) = 4621.2 |
| Arteriovenous shunt with graft | ||||||
| TISSEEL 2C (24) | 64(14.6) | 12 (50) | Bypass grafting | NR | Mean heparin units (IU) = 5804.2 | |
| Arteriovenous shunt with graft | ||||||
| Manual Compression (23) | 63(14.4) | 11 (48) | Bypass grafting | NR | Mean heparin units (IU) = 5731.8 | |
| Arteriovenous shunt with graft | ||||||
| Chalmers 2010 [29] | EVICEL 1C (75) | 66(11) | 41 (55) | Femoral procedures | Heparin: 70IU/kg for bypass and 35IU/kg for AVG. Protamine in 5–7% | |
| Bypass grafting | 44 (58.7%) | |||||
| Arteriovenous access graft | 1 (1.3%) | |||||
| Aneurysm graft | 3 (4%) | |||||
| Upper extremity graft procedures | 27 (36%) | |||||
| Manual Compression (72) | 66(14) | 36 (50) | Femoral procedures | |||
| Bypass grafting | 48 (66.7%) | |||||
| Arteriovenous access graft | 3 (4.2%) | |||||
| Aneurysm graft | 0 | |||||
| Upper extremity graft procedures | 21 (29.2%) | |||||
Abbreviations: 1C = 1-min clotting time; 2C = 2-min clotting time; AVG = arteriovenous graft; IU = international unit, NR = not reported; n = number of patients; SD = standard deviation. characteristics.