Fig. 7.
Propranolol reduces mean arterial blood pressure in hypoxia but not normoxia. a Example in vivo traces demonstrating 10 min of recording of arterial blood pressure (ABP; upper) and heart rate (HR; lower) during normoxia and hypoxia (10% FiO2) for N, N + Prop, CIH and CIH + Prop animals. b–d Mean arterial blood pressure (MABP) measured in normoxia and hypoxia, and the calculated change (hypoxia-normoxia) for N (n = 8), N + Prop (n = 9), CIH (n = 8) and CIH + Prop (n = 7) animals. e–g HR recorded in normoxia and hypoxia, and the calculated difference (hypoxia-normoxia). Individual points are each from a single animal. Data presented as box and whisker plots with median; the 25th and 75th percentiles form the box and whiskers extend to minimum and maximum values. Overall effects of CIH and Propranolol are shown as text; two-way ANOVA with Tukey’s multiple-comparisons test