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. 2021 Jan 4;12:74. doi: 10.1038/s41467-020-20434-3

Fig. 2. Trim28 adi-KO increases adiposity but preserves glucose homeostasis in male and female mice fed a chow diet.

Fig. 2

Total body weight of male (a) and female (b) Trim28 WT and adi-KO (KO) mice over 22-week study period on chow diet. Body composition including body mass and fat mass presented as percent body weight (BW) for (c) male mice and (d) female mice from 6 weeks of age. Fasting blood glucose and oral glucose tolerance test in male and female mice with corresponding incremental area under the curve (iAUC) at 6 weeks of age (e–h; basal), 10 weeks of age (i–l; mid-study), and 22 weeks of age (m–p; end of study). All data are presented as mean ± SEM, female mice n = 11 WT and n = 11 KO, and male mice n = 12 WT and n = 11 KO. All data were analyzed using two-way ANOVA where *p < 0.05, or repeated measures mixed-effects model where #p < 0.05 for time × genotype interaction.