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. 2021 Jan 4;4:20. doi: 10.1038/s42003-020-01557-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Changes in RNA expression of the BH3-only genes in human adult OLs due to glucose deprivation. Average RNA expression levels of members of the BH3-only family in media containing low concentration of glucose (LG) or in optimal culture media (N1) derived by microarray analysis of human adult OLs. N = 3 independent biological samples. b–d Effects of inhibition of the BCL-2 family on cell death of human adult OLs. Cells were cultured in optimal culture media (N1) and in media with no glucose (NG) and treated with the specific inhibitor of BCL-XL WEHI-539 and the non-specific inhibitor ABT737 in N1 and NG media for two days. Cells treated only with DMSO were used as the vehicle control. N = 3 independent biological samples. Data are presented as (b) number of cells present; c %PI+ cells and d %TUNEL+ cells. Mean ± SEM for each condition in the figure. Significant levels for the ANOVA/Dunnett’s test for paired samples with DMSO as reference: *(<0.05), **(<0.01).