Table 2.
Ranking of SARS-CoV-2 antigens for IgM.
| Rank | Antigen | Sensitivity | Specificity | AUC |
|---|---|---|---|---|
| 1 | SARS.CoV.2.Spike.RBD.rFc | 0.5894 | 0.9873 | 0.987 |
| 2 | SARS.CoV.2.S1.HisTag | 0.6238 | 0.9867 | 0.9866 |
| 3 | SARS.CoV.2.S1 | 0.2198 | 0.9858 | 0.9854 |
| 4 | SARS.CoV.2.S1.mFcTag | 0.1389 | 0.9855 | 0.9852 |
| 5 | SARS.CoV.2.S2 | 0.474 | 0.9851 | 0.9848 |
| 6 | SARS.CoV.2.Spike.RBD.His.HEK | 0.6915 | 0.9843 | 0.9842 |
| 7 | SARS.CoV.2.NP | 0.0595 | 0.9844 | 0.9839 |
| 8 | SARS.CoV.2.S1.RBD | 0.5929 | 0.9839 | 0.9836 |
| 9 | SARS.CoV.2.S1+S2 | 0.5704 | 0.9839 | 0.9836 |
| 10 | SARS.CoV.2.Spike.RBD.Bac | 0.2222 | 0.9829 | 0.9827 |
| 11 | SARS.CoV.2.Pl.pro | 0.0413 | 0.9817 | 0.9809 |
Test performance characteristics for discrimination of positive and negative sera were derived for each individual antigen using ROC analysis with high specificity threshold, with top-performing antigen in bold.